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Protecting Groups for Alcohols: Silyl Ethers | 12.5 Organic Chemistry

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Chemistry

Chad introduces silyl ethers (trimethyl silyl ethers specifically) as protecting groups for alcohols. He first explains why and when an alcohol protecting group might be needed and provides an example. He then shows the mechanism for the formation of a silyl ether and the removal of it using TBAF (tetrabutylammonium fluoride).

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00:00 Lesson Introduction
00:39 The Need for Alcohol Protecting Groups
02:52 Silyl Ethers as Alcohol Protecting Groups
06:21 Removal of Protecting Groups with H3O+ or TBAF

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