Malonic & Acetoacetic Ester Synthesis | 21.7 Organic Chemistry

Chad provides a comprehensive lesson on the Malonic Ester Synthesis and the Acetoacetic Ester Synthesis. Both of these are examples of a ‘template synthesis’ in which a certain type of product is formed with variation on the attached alkyl groups depending on which reagents are specifically used. The lesson begins with a description of Beta-Decarboxylation as this is a component in both of these template syntheses including the mechanism of the key step. Next, the Malonic Ester Synthesis is shown to produce carboxylic acids which vary only in which alkyl group(s) is/are attached to the alpha carbon. Finally, the Acetoacetic Ester Synthesis is shown to produce methyl ketones which vary only in which alkyl group(s) is/are attached to the alpha carbon.

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00:00 Lesson Introduction
01:21 Beta-Decarboxylation
05:39 Malonic Ester Synthesis
12:45 Acetoacetic Ester Synthesis

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