Metabolism | Triglyceride Synthesis

📚 Premium Notes & Illustrations for Triglyceride Synthesis: https://www.ninjanerd.org/lecture/triglyceride-synthesis-2

Ninja Nerds!
In this metabolism lecture, Professor Zach Murphy guides you through the process of Triglyceride Synthesis. This essential anabolic pathway allows the body to store energy in the form of fat. This lecture connects the dots between carbohydrate metabolism and lipid storage, emphasizing how glycerol-3-phosphate and fatty acyl-CoA form triacylglycerols (TAGs) in the liver and adipose tissue.

We begin by reviewing how glycerol-3-phosphate is derived from glycolysis or glycerol kinase, and how fatty acids, synthesized or taken up from circulation, are activated by acyl-CoA synthetase. You’ll learn how these substrates are sequentially esterified by enzymes like GPAT, AGPAT, and DGAT to form a complete triglyceride molecule.

The lecture also covers tissue-specific differences, highlighting how the liver packages triglycerides into VLDL for export, while adipose tissue stores triglycerides for future energy use. We discuss the hormonal regulation of this pathway, including insulin’s stimulatory role during the fed state and how triglyceride synthesis is coordinated with glycolysis and fatty acid synthesis.

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