Metabolism | Glycolysis

📚 Premium Notes & Illustrations for Glycolysis: https://www.ninjanerd.org/lecture/glycolysis-2

Ninja Nerds!
In this metabolism lecture, Professor Zach Murphy walks you step-by-step through Glycolysis, the central metabolic pathway that breaks down glucose into pyruvate while generating ATP and NADH. This lecture builds a solid biochemical foundation for understanding energy production in both aerobic and anaerobic conditions, and it sets the stage for deeper dives into the citric acid cycle, oxidative phosphorylation, and beyond.

We begin by outlining the ten enzymatic steps of glycolysis, from the phosphorylation of glucose by hexokinase to the final conversion of phosphoenolpyruvate to pyruvate via pyruvate kinase. Key regulatory enzymes—hexokinase, phosphofructokinase-1 (PFK-1), and pyruvate kinase—are highlighted, including how they respond to energy status and hormonal signals to control the pathway’s rate.

The lecture also distinguishes between the energy investment phase and the energy payoff phase, showing how ATP is consumed and then generated along with the production of NADH. We emphasize the importance of glycolysis in various tissue types—especially RBCs, muscle, and cancer cells—and discuss how it functions under both aerobic and anaerobic conditions.

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Table of Contents:
00:00 Lab
01:29 Glucose (Glut) Transporters
06:30 Glucose-6-Phosphate
10:20 Fructose-6-Phosphate
11:40 Fructose-1,6-biphosphate
14:00 Dihydroxy Acetone Phosphate / Glyceraldehyde-3-Phosphate
17:24 1,3-biphosphoglycerate
20:30 3-phosphoglycerate
22:30 2-phosphoglycerate
23:40 Phosphoenol-pyruvate (PEP)
25:25 Pyruvate Kinase
27:10 Anaerobic
30:55 Comment, Like SUBSCRIBE!

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