Metabolism | Electron Transport Chain: DETAILED | Part 3

📚 Premium Notes & Illustrations for Electron Transport Chain Part 3: https://www.ninjanerd.org/lecture/electron-transport-chain-detailed-part-3-4

Ninja Nerds!
In Part 3 of our Electron Transport Chain series, Professor Zach Murphy wraps up the final piece of mitochondrial energy production by covering the regulation of the ETC, the effects of inhibitors and uncouplers, and key clinical correlations. This lecture ties together the previous two parts by examining how the efficiency and safety of oxidative phosphorylation are tightly controlled—and how disruptions can lead to profound cellular dysfunction.

We begin by outlining the major regulatory factors of the ETC, including ADP availability, oxygen concentration, and NADH/FADH₂ supply, emphasizing how cellular energy demand dynamically modulates electron flow and ATP synthesis. From there, we dive into high-yield toxins and pharmacologic agents that inhibit specific complexes—such as rotenone (Complex I), antimycin A (Complex III), cyanide and carbon monoxide (Complex IV), and oligomycin (ATP synthase).

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