Peroxisomes Structure & Function

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Ninja Nerds!
In this cell biology lecture, Professor Zach Murphy breaks down the structure and function of Peroxisomes, small but essential organelles involved in lipid metabolism, detoxification, and reactive oxygen species regulation. This lecture offers a focused look at how peroxisomes contribute to cellular homeostasis and how their dysfunction leads to serious metabolic disease.

We begin by exploring peroxisomal biogenesis and protein import, followed by a review of their key functions—β-oxidation of very long-chain fatty acids, metabolism of branched-chain fatty acids, plasmalogen synthesis, and hydrogen peroxide breakdown via catalase.

The lecture then highlights clinical correlations through high-yield disorders such as Zellweger Syndrome, Refsum’s Disease, and X-linked Adrenoleukodystrophy. We explain the underlying enzymatic defects, pathophysiology, and characteristic clinical presentations associated with each disorder.

Whether you’re studying basic cell function or diving into inherited metabolic diseases, this lecture gives you a strong grasp of peroxisomal biology and its relevance to human health.

Enjoy the lecture and support us below!

Table of Contents:
0:00 Lab
0:07 Peroxisomes Structure & Function Introduction
0:29 Peroxisomes Structure
0:56 Fatty Acid Oxidation
4:16 Hydrogen Peroxide Metabolism
7:22 Biosynthetic Functions
12:09 Ethanol Metabolism
16:02 Comment, Like, SUBSCRIBE!

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