Pedigree Analysis Example Haemophilia | X-linked Recessive Pedigree NEET Class 12 | Neela Bakore

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Haemophilia pedigree solved — X-linked recessive inheritance, genotype assignment.

📌 Topics Covered:
• Identifying X-linked recessive pattern
• Reading the Haemophilia pedigree generation by generation
• Genotypes: carrier female (XᴴXʰ), affected male (XʰY)
• Why haemophilia skips generations
• Historical reference: Queen Victoria’s family
• NEET MCQ approach
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Transcript with Timestamp
0:00 Introduction — Sex-linked pedigree using Haemophilia
0:31 Question: woman (father was haemophilic) × normal man → 2 daughters + 1 son
1:57 Plot pedigree: grandfather (haemophilic) + grandmother → proband woman
2:25 Haemophilia = X-linked recessive
2:48 Haemophilic father: XʰY; Normal man: XᴴY
4:04 Proband woman received Xʰ from haemophilic father → she is a CARRIER (XᴴXʰ)
5:13 Grandmother: could be carrier or normal (2 possibilities)
6:21 Offspring of carrier woman × normal man:
6:48 Son: receives Y from father → gets Xᴴ or Xʰ from mother → 50% normal, 50% diseased
7:09 Daughters: receive Xᴴ from father → get XᴴorXʰ from mother → 50% normal, 50%
carrier
7:39 Daughters of normal father CANNOT be diseased
8:24 NEET tip: ‘what % of daughters are diseased?’ → 0% if father is normal
9:24 Conditions for diseased daughter: father must be diseased + mother must be at least
carrier
9:38 Summary — autosomal vs X-linked pedigree comparison
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