Metabolism | Regulation of Glycolysis

📚 Premium Notes & Illustrations for Regulation of Glycolysis: https://www.ninjanerd.org/lecture/regulation-of-glycolysis-2

Ninja Nerds!
In this metabolism lecture, Professor Zach Murphy breaks down the Regulation of Glycolysis, focusing on how cells control the rate of glucose breakdown to meet energy demands. This lecture builds on your understanding of the glycolytic pathway by exploring the allosteric, hormonal, and energy-status-based mechanisms that fine-tune its activity in real time.

We begin by identifying the key regulatory enzymes—hexokinase, phosphofructokinase-1 (PFK-1), and pyruvate kinase—and how they serve as metabolic control points. You’ll learn how ATP, AMP, citrate, and fructose-2,6-bisphosphate act as powerful allosteric modulators, reflecting the cell’s energetic state and driving glycolysis up or down accordingly.

The lecture also discusses the role of insulin and glucagon in hormonal regulation, particularly through PFK-2/FBPase-2 and the synthesis of fructose-2,6-bisphosphate, which links glycolysis to gluconeogenesis in liver metabolism. We explain how fed vs. fasting states, exercise, and tissue-specific needs alter the expression and activity of glycolytic enzymes.

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