Linkage & Gene Mapping | Morgan Experiment Crossing Over | NEET Biology Class 12 | Neela Bakore
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Linkage and Gene Mapping — Morgan’s experiments, crossing over, and centiMorgan distances.
📌 Topics Covered:
• Complete vs Incomplete Linkage
• Morgan’s Drosophila: body colour + wing type linkage
• Cis (coupling) vs Trans (repulsion) configuration
• Recombination frequency = map distance (centiMorgan)
• Three-point test cross and chromosome mapping
• Exception to Law of Independent Assortment
• NEET PYQs on linkage
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Transcript with Timestamp
0:00 Introduction — Linkage and linked genes
0:38 Genes on same chromosome — linked. Closer = less separation.
2:44 Two types: Complete Linkage & Incomplete Linkage
2:53 Complete Linkage — separation not possible
3:10 Morgan’s Drosophila: grey body + normal wings linked; black body + vestigial wings
linked
4:15 Cross: grey normal (homozygous) × black vestigial
4:46 F2 expected 9:3:3:1 BUT with complete linkage → 8:8 ratio (only 2 phenotypes)
5:25 Incomplete Linkage — genes can separate via crossing over
5:40 Other examples: rice (grain colour + productivity); cotton (corolla colour + lint index)
6:41 Significance: linked genes used as markers
7:49 Linkage Groups = number of chromosomes in ONE haploid set (n)
8:21 Humans: n = 23 → 23 linkage groups; Drosophila: n = 4 → 4 linkage groups
9:40 Gene Mapping — determining gene positions on chromosome
11:56 Recombination frequency → map units (1 map unit = 1% recombination frequency)
12:21 1 map unit = 1 centiMorgan (cM)
13:40 Example: A-B = 20 map units; A-C = 10 map units → two possible arrangements: CAB or ACB
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