Metabolism | The Metabolic Map: Proteins

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Ninja Nerds!
In this final lecture of our Metabolic Map series, Professor Zach Murphy presents an integrated overview of Protein Metabolism, tying together the pathways of amino acid breakdown, synthesis, and nitrogen disposal. This big-picture approach helps you see how protein metabolism connects with carbohydrate and lipid pathways, especially during states of fasting, stress, and muscle catabolism.

We begin by outlining how dietary proteins are digested into amino acids, which serve as building blocks for protein synthesis or as substrates for gluconeogenesis, ketogenesis, or energy production. The lecture then walks through transamination and deamination reactions, emphasizing how amino groups are transferred to form glutamate, which is then released as free ammonia for detoxification through the urea cycle.

You’ll learn how carbon skeletons are classified as glucogenic, ketogenic, or both, and how they feed into key hubs like pyruvate, acetyl-CoA, or TCA cycle intermediates, depending on metabolic state. Hormonal influences—particularly glucagon, cortisol, and insulin—are discussed to show how protein metabolism is regulated during catabolic and anabolic conditions.

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