Metabolism | The Metabolic Map: Carbohydrates

📚 Premium Notes & Illustrations for Metabolic Map: Carbohydrates: https://www.ninjanerd.org/lecture/the-metabolic-map-carbohydrates-2

Ninja Nerds!
In this lecture, Professor Zach Murphy kicks off our Metabolic Map series by tracing the major pathways of Carbohydrate Metabolism, helping you visualize how glucose flows through various interconnected biochemical routes. This lecture serves as a big-picture overview that ties together everything you’ve learned—highlighting how carbohydrate-derived intermediates are directed based on energy needs and metabolic state.

We begin with glycolysis, gluconeogenesis, and glycogen metabolism, then explore how glucose enters the pentose phosphate pathway for NADPH production and nucleotide synthesis. You’ll see how glycolytic intermediates feed into fatty acid synthesis, while excess acetyl-CoA links carbohydrate metabolism to lipogenesis and the TCA cycle. Emphasis is placed on hormonal regulation—especially insulin and glucagon—and how these signals shift metabolic priorities between fed and fasting states.

By mapping out these interconnected pathways, you’ll develop a systems-level understanding of how the body stores, uses, and redirects carbohydrates depending on physiologic demand. This foundation sets the stage for the next parts of our series, which cover lipid and protein metabolism in the same integrated fashion.

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