Metabolism | Pentose Phosphate Pathway

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Ninja Nerds!
In this metabolism lecture, Professor Zach Murphy breaks down the Pentose Phosphate Pathway (PPP)—a vital, alternate glucose metabolism pathway that branches from glycolysis to generate NADPH and ribose-5-phosphate. This lecture helps you understand how cells use this pathway for biosynthesis, antioxidant defense, and nucleotide production, especially in metabolically active tissues.

We begin by dividing the PPP into its two phases: the oxidative phase, which produces NADPH via glucose-6-phosphate dehydrogenase (G6PD), and the non-oxidative phase, which interconverts sugars like ribose-5-phosphate, fructose-6-phosphate, and glyceraldehyde-3-phosphate for use in nucleotide synthesis or glycolysis. You’ll learn how NADPH is essential for fatty acid synthesis, cholesterol biosynthesis, and glutathione regeneration, particularly in red blood cells.

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